Preparation of 6-fluoro-8-quinolinol and related 6-fluoroquinolines / Herman Gershon, Donald D. Clarke, and Muriel Gershon Department of Chemistry, Fordham University, Bronx, New York 10458 U.S.A., New York Botanical Garden, Bronx, New York 10458, U.S.A.

Authors

Herman Gershon, New York Botanical Garden. Harding Laboratory
Donald Dudley Clarke PhD, Fordham UniversityFollow
Muriel Gershon, New York Botanical Garden. Harding Laboratory

Document Type

Article

Keywords

6-Fluoro-8-quinolinol, Antifungal activity

Disciplines

Biochemistry

Abstract

6-Fluoro-8-quinolinol was prepared from 2-amino-5-fluorophenol by a Skraup synthesis. No synergism was observed between 5-fluoro- and 6-fluoro-8-quinolinols or between 6-fluoro-8-quinolinolsuoro- and 7-fluoro-8-quinolinols against any of the six fungi in our test system (Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, and Trichophyton mentagrophytes) in Sabouraud dextrose broth. Unlike the fluoro-8-quinolinols, the 8-quinolinols comparably substituted with chlorine or bromine did form synergistic mixtures. This is attributed to steric factors

Article Number

1050

Publication Date

2002

Recommended Citation

Gershon, Herman; Clarke, Donald Dudley PhD; and Gershon, Muriel, "Preparation of 6-fluoro-8-quinolinol and related 6-fluoroquinolines / Herman Gershon, Donald D. Clarke, and Muriel Gershon Department of Chemistry, Fordham University, Bronx, New York 10458 U.S.A., New York Botanical Garden, Bronx, New York 10458, U.S.A." (2002). Chemistry Faculty Publications. 51.
https://research.library.fordham.edu/chem_facultypubs/51

Comments

Monatshefte für chemie 133:1437-1442. http://dx.doi.org/10.1007/s00706-002-0513-8