Preparation and fungitoxicity of some dichloro-8-quinolinols / Herman Gershon, Donald D. Clarke, and Muriel Gershon Department of Chemistry, Fordham University, Bronx, NY 10458, USA New York Botanical Garden, Bronx, NY 10458, USA

Authors

Herman Gershon, New York Botanical Garden. Harding Laboratory
Donald Dudley Clarke PhD, Fordham UniversityFollow
Muriel Gershon, New York Botanical Garden. Harding Laboratory

Document Type

Article

Keywords

Dichloro-8-quinolinols, Antifungal activity, Intramolecular synergism

Disciplines

Biochemistry

Abstract

2,5-, 3,5-, 3,7-, 4,5-, 5,6-, und 6,7-Dichloro-8-quinolinols were prepared and tested along with their 3,6- and 5,7-ana1ogues against six fungi (Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, and Trichophyton mentagrophytes) in Sabouraud dextrose broth. Most of the compounds were strongly antifungal, inhibiting five of the fungi below 1 μg/ml. This activity is attributed to intramolecular synergism. M. cirinelloides was inhibited less by these compounds

Article Number

1054

Publication Date

1999

Recommended Citation

Gershon, Herman; Clarke, Donald Dudley PhD; and Gershon, Muriel, "Preparation and fungitoxicity of some dichloro-8-quinolinols / Herman Gershon, Donald D. Clarke, and Muriel Gershon Department of Chemistry, Fordham University, Bronx, NY 10458, USA New York Botanical Garden, Bronx, NY 10458, USA" (1999). Chemistry Faculty Publications. 55.
https://research.library.fordham.edu/chem_facultypubs/55

Comments

Monatshefte für chemie 130:653-659. http://dx.doi.org/10.1007/PL00010246