Document Type
Article
Keywords
antifungal activity, halogenated 8-quinolinol-5- and 7-sulfonic acids, halogenated 8-quinolinol-2- methyl-5- and 7-sulfonic acids, intramolecular synergism
Disciplines
Biochemistry
Abstract
8-Quinolinol-5-sulfonic acid was nearly devoid of antimicrobial activity, due to what was believed to be an unfavorable partition coefficient. Since twenty six 8-quinolinol-5- and 7 -sulfonic acids were available from our previous work, they were tested against six fungi. The 7 -chloro and 7 -bromo-5-sulfonic acids and the 5-chloro and 5-bromo-7 -sulfonic acids showed fungal inhibition within one order of magnitude of that of 8-quinolinol. It is suggested that a nonchelating mechanism is in part responsible for this fungitoxicity. Five additional 5-sulfonic acids with chlorine in positions 3-, 6-, 3,6-, 3,7-, and 6,7- that were suitable for studies in synergism became available more recently. The enhanced activities of the dichlorosulfonic acids over the correspondingly substituted monochlorosulfonic acids is attributed to intramolecular synergism
Article Number
1011
Publication Date
2001
Recommended Citation
Gershon, Herman; Gershon, Muriel; and Clarke, Donald Dudley PhD, "Antifungal activity of substituted 8-quinolinol-5- and 7-sulfonic acids: a mechanism of action is suggested based on intramolecular synergism / Hermon Gershon, Muriel Gershon, & Donald D. Clarke Harding Laboratory, The New York Botanical Garden, Bronx, New York 10458, USA; Department of Chemistry, Fordham University, Bronx, New York 10458, USA" (2001). Chemistry Faculty Publications. 12.
https://research.library.fordham.edu/chem_facultypubs/12
Comments
Mycopathologia 155:213-217