Preparation and fungitoxicity of some trichloro-, tribromo-, tetrachloro-, and tetrabromo-8-quinolinols / Herman Gershon, Donald D. Clarke, and Muriel Gershon Department of Chemistry, Fordham University, Bronx, New York 10458-9993 USA, New York Botanical Garden, Bronx, New York 10458-9993 USA

Authors

Herman Gershon, New York Botanical Garden. Harding Laboratory
Donald Dudley Clarke PhD, Fordham UniversityFollow
Muriel Gershon, New York Botanical Garden. Harding Laboratory

Document Type

Article

Keywords

Trichloro-8-quinolinols, Tribromo-8-quinolinols, Tetrachloro-8-quinolinols, Tetrabromo-8-quinolinols, Antifungal activity

Disciplines

Biochemistry

Abstract

3,5,6-, 3,5,7-, 4,5,7-, and 5,6,7-trichloro- and -tribromo-8-quinolinols as well as 3,5,6,7- tetrachloro- and -tetrabromo-8-quinolinols were prepared and tested against six fungi (Aspergillus niger, Aspergillus oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, and Trichophyton mentagrophytes) in Sabouraud dextrose broth. The compounds strongly inhibit five fungi but not M. cirinelloides. They are less active than the related dichloro-8-quinolinols which is attributed to steric hindrance

Article Number

1052

Publication Date

2001

Recommended Citation

Gershon, Herman; Clarke, Donald Dudley PhD; and Gershon, Muriel, "Preparation and fungitoxicity of some trichloro-, tribromo-, tetrachloro-, and tetrabromo-8-quinolinols / Herman Gershon, Donald D. Clarke, and Muriel Gershon Department of Chemistry, Fordham University, Bronx, New York 10458-9993 USA, New York Botanical Garden, Bronx, New York 10458-9993 USA" (2001). Chemistry Faculty Publications. 53.
https://research.library.fordham.edu/chem_facultypubs/53

Comments

Monatshefte für chemie 132:1075-1080. http://dx.doi.org/10.1007/s007060170048