Preparation and fungitoxicity of 3-bromo-6-chloro- and 6-bromo-3-chloro-8-quinolinols / Gershon H., Clarke D. D., Gerhson M, Department of Chemistry, Fordham University, Bronx, NY 10458, USA, New York Botanical Garden, Bronx, NY 10458, USA

Authors

Herman Gershon, Fordham University
Donald Dudley Clarke PhD, Fordham UniversityFollow
Muriel Gershon, New York Botanical Garden

Document Type

Article

Keywords

3-Bromo-6-chloro-8-quinolinol, 6-Bromo-3-chloro-8-quinolinol, 3-Bromo-6,8-dihydroxyquinoline, 3-Chloro-6,8-dihydroxyquinoline, Fungitoxicity

Disciplines

Biochemistry

Abstract

3-Bromo-6-chloro- and 6-bromo-3-chloro-8-nitro, -8-amino-, and -8-hydroxyquinolines along with 3-bromo- and 3-chloroquinolin-6,8-diols were prepared and tested for antifungal activity against six fungi (Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, Trichophyton mentagrophytes) in Sabouraud dextrose broth. Compounds with chlorine in the 3 position were generally more fungitoxic than the corresponding analogues with bromine. 6-Bromo-3-chloro-8-quinolinol inhibited four fungi at levels below 1 μg/ml and A. niger and M. cirinelloides at 2 μg/ml each

Article Number

1080

Publication Date

1996

Recommended Citation

Gershon, Herman; Clarke, Donald Dudley PhD; and Gershon, Muriel, "Preparation and fungitoxicity of 3-bromo-6-chloro- and 6-bromo-3-chloro-8-quinolinols / Gershon H., Clarke D. D., Gerhson M, Department of Chemistry, Fordham University, Bronx, NY 10458, USA, New York Botanical Garden, Bronx, NY 10458, USA" (1996). Chemistry Faculty Publications. 83.
https://research.library.fordham.edu/chem_facultypubs/83

Comments

Monatshefte für Chemie 127:331-337. http://dx.doi.org/10.1007/BF00813800