Synthesis and Structure-lethality Relationships of 2,2-bis(Para-chlorophenyl)-1,1,2-trisubstituted Ethane Compounds
Abstract
Since the discovery of the outstanding insecticidal activity of 1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane (DDT) by Müller of the J. R. Geigy, A.-G., in Switzerland in 1939, the synthesis and testing of related compounds have been actively pursued in many laboratories. These in- vestigations were motivated not only by the desire to find compounds with greater toxicity than DDT, but also by the development of widespread resistance to DDT2 and the long life of DDT residues. 3,4,5In keeping with the over-all objective of studying structure-lethality relationships, the synthesis of closely related members of an entire family of compounds was under- taken. These compounds were tested for lethality to house flies, Musca domestica, and mosquitoes, Anopheles albimanus (A. alb.) and Culex quinquefasciatus (C. 5-fasc.) in the WHO primary screen at Riverside, California.
Subject Area
Organic chemistry
Recommended Citation
DEMARCO, JOHN GREGORY, "Synthesis and Structure-lethality Relationships of 2,2-bis(Para-chlorophenyl)-1,1,2-trisubstituted Ethane Compounds" (1967). ETD Collection for Fordham University. AAI6711488.
https://research.library.fordham.edu/dissertations/AAI6711488
